SPEN Loss Drives Extrafollicular Diffuse Large B-cell Lymphoma with Female-Specific Lethality and Therapeutic Vulnerabilities

Benedikt Pelzer, Cem Meydan, Isaac M. Spiegel, Ioannis Karagiannidis, Min Xia, Matt Teater, Emma M. Welter, Zowie E. Searcy, Laura K. Hilton, Darko Barisic, Amos Fong, Pengyan Fa, Shenon Sethi, Irem S. Isgor, Jessie J. Fielding, Alireza Karbalayghareh, Colin S. Burdette, Sravya Tumuluru, Sonia M. Debek, Sunjae Lee, Ramon Massoni-Badosa, Ceyda Durmaz, Eralda Salataj, Prasath Pararajalingam, Zhengming Chen, Richard J. Pelzl, Sanket Shah, Martin A. Rivas, Kenneth B. Hoehn, Coraline Mlynarczyk, Hannah M. Isles, Xiang Wang, Ahmet Dogan, Kojo S.J. Elenitoba-Johnson, David W. Scott, Kostiantyn Dreval, Ryan D. Morin, Christina S. Leslie, Rishi Puri, Jacob B. Geri, Christopher R. Chin, Amy Chadburn, Christopher E. Mason, Hans Christian Reinhardt, Montserrat C. Anguera, Wendy Béguelin, Leandro Venturutti, Ari M. Melnick
April 2026
DOI
Type
Journal article
Publication
Cancer Discovery 16(8), 1666–1690
Alireza Karbalayghareh
Alireza Karbalayghareh
Senior Research Scientist, AI/ML

My research focuses on developing universal AI models of gene regulation, capturing cis-regulation, trans-regulation, and intercellular signaling by integrating multimodal, multiomic observational, spatial, time-resolved, and perturbational data from immune cells across diverse biological contexts to understand and engineer the immune system to prevent and treat disease.